ParkinsonCanadaV1, Main, Exploration, bibRecord, 000430

Bilateral deep brain stimulation of the fornix for Alzheimer's disease: surgical safety in the ADvance trial.

Identifieur interne : 000430 ( Main/Exploration ); précédent : 000429; suivant : 000431

Bilateral deep brain stimulation of the fornix for Alzheimer's disease: surgical safety in the ADvance trial.

Auteurs : Francisco A. Ponce ; Wael F. Asaad ; Kelly D. Foote ; William S. Anderson ; G. Rees Cosgrove ; Gordon H. Baltuch [États-Unis] ; Kara Beasley [États-Unis] ; Donald E. Reymers ; Esther S. Oh ; Steven D. Targum ; Gwenn S. Smith [États-Unis] ; Constantine G. Lyketsos [États-Unis] ; Andres M. Lozano [Canada]

Source :

Journal of neurosurgery [ 1933-0693 ] ; 2016.

RBID : pubmed:26684775

Abstract

OBJECT This report describes the stereotactic technique, hospitalization, and 90-day perioperative safety of bilateral deep brain stimulation (DBS) of the fornix in patients who underwent DBS for the treatment of mild, probable Alzheimer's disease (AD). METHODS The ADvance Trial is a multicenter, 12-month, double-blind, randomized, controlled feasibility study being conducted to evaluate the safety, efficacy, and tolerability of DBS of the fornix in patients with mild, probable AD. Intraoperative and perioperative data were collected prospectively. All patients underwent postoperative MRI. Stereotactic analyses were performed in a blinded fashion by a single surgeon. Adverse events (AEs) were reported to an independent clinical events committee and adjudicated to determine the relationship between the AE and the study procedure. RESULTS Between June 6, 2012, and April 28, 2014, a total of 42 patients with mild, probable AD were treated with bilateral fornix DBS (mean age 68.2 ± 7.8 years; range 48.0-79.7 years; 23 men and 19 women). The mean planned target coordinates were x = 5.2 ± 1.0 mm (range 3.0-7.9 mm), y = 9.6 ± 0.9 mm (range 8.0-11.6 mm), z = -7.5 ± 1.2 mm (range -5.4 to -10.0 mm), and the mean postoperative stereotactic radial error on MRI was 1.5 ± 1.0 mm (range 0.2-4.0 mm). The mean length of hospitalization was 1.4 ± 0.8 days. Twenty-six (61.9%) patients experienced 64 AEs related to the study procedure, of which 7 were serious AEs experienced by 5 patients (11.9%). Four (9.5%) patients required return to surgery: 2 patients for explantation due to infection, 1 patient for lead repositioning, and 1 patient for chronic subdural hematoma. No patients experienced neurological deficits as a result of the study, and no deaths were reported. CONCLUSIONS Accurate targeting of DBS to the fornix without direct injury to it is feasible across surgeons and treatment centers. At 90 days after surgery, bilateral fornix DBS was well tolerated by patients with mild, probable AD. Clinical trial registration no.: NCT01608061 ( clinicaltrials.gov ).

DOI: 10.3171/2015.6.JNS15716
PubMed: 26684775

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Bilateral deep brain stimulation of the fornix for Alzheimer's disease: surgical safety in the ADvance trial.</title>
<author><name sortKey="Ponce, Francisco A" sort="Ponce, Francisco A" uniqKey="Ponce F" first="Francisco A" last="Ponce">Francisco A. Ponce</name>
<affiliation><nlm:affiliation>Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona; </nlm:affiliation>
<wicri:noCountry code="subField">Arizona; </wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Asaad, Wael F" sort="Asaad, Wael F" uniqKey="Asaad W" first="Wael F" last="Asaad">Wael F. Asaad</name>
<affiliation><nlm:affiliation>Departments of 2 Neurosurgery and.</nlm:affiliation>
<wicri:noCountry code="no comma">Departments of 2 Neurosurgery and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Foote, Kelly D" sort="Foote, Kelly D" uniqKey="Foote K" first="Kelly D" last="Foote">Kelly D. Foote</name>
<affiliation><nlm:affiliation>Department of Neurosurgery, University of Florida, Gainesville, Florida; </nlm:affiliation>
<wicri:noCountry code="subField">Florida; </wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Anderson, William S" sort="Anderson, William S" uniqKey="Anderson W" first="William S" last="Anderson">William S. Anderson</name>
<affiliation><nlm:affiliation>Departments of 5 Neurological Surgery.</nlm:affiliation>
<wicri:noCountry code="no comma">Departments of 5 Neurological Surgery.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rees Cosgrove, G" sort="Rees Cosgrove, G" uniqKey="Rees Cosgrove G" first="G" last="Rees Cosgrove">G. Rees Cosgrove</name>
<affiliation><nlm:affiliation>Departments of 2 Neurosurgery and.</nlm:affiliation>
<wicri:noCountry code="no comma">Departments of 2 Neurosurgery and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Baltuch, Gordon H" sort="Baltuch, Gordon H" uniqKey="Baltuch G" first="Gordon H" last="Baltuch">Gordon H. Baltuch</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Neurosurgery, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Beasley, Kara" sort="Beasley, Kara" uniqKey="Beasley K" first="Kara" last="Beasley">Kara Beasley</name>
<affiliation wicri:level="2"><nlm:affiliation>Boulder Neurosurgical & Spine Associates, Boulder, Colorado;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
<wicri:cityArea>Boulder Neurosurgical & Spine Associates, Boulder</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Reymers, Donald E" sort="Reymers, Donald E" uniqKey="Reymers D" first="Donald E" last="Reymers">Donald E. Reymers</name>
<affiliation><nlm:affiliation>Functional Neuromodulation Ltd., Minneapolis, Minnesota; and.</nlm:affiliation>
<wicri:noCountry code="subField">Minnesota; and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Oh, Esther S" sort="Oh, Esther S" uniqKey="Oh E" first="Esther S" last="Oh">Esther S. Oh</name>
<affiliation><nlm:affiliation>Medicine, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Targum, Steven D" sort="Targum, Steven D" uniqKey="Targum S" first="Steven D" last="Targum">Steven D. Targum</name>
<affiliation><nlm:affiliation>Functional Neuromodulation Ltd., Minneapolis, Minnesota; and.</nlm:affiliation>
<wicri:noCountry code="subField">Minnesota; and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Smith, Gwenn S" sort="Smith, Gwenn S" uniqKey="Smith G" first="Gwenn S" last="Smith">Gwenn S. Smith</name>
<affiliation wicri:level="2"><nlm:affiliation>Psychiatry, Johns Hopkins University, Baltimore, Maryland;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Psychiatry, Johns Hopkins University, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lyketsos, Constantine G" sort="Lyketsos, Constantine G" uniqKey="Lyketsos C" first="Constantine G" last="Lyketsos">Constantine G. Lyketsos</name>
<affiliation wicri:level="2"><nlm:affiliation>Psychiatry, Johns Hopkins University, Baltimore, Maryland;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Psychiatry, Johns Hopkins University, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Neurosurgery, University of Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurosurgery, University of Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="2016">2016</date>
<idno type="RBID">pubmed:26684775</idno>
<idno type="pmid">26684775</idno>
<idno type="doi">10.3171/2015.6.JNS15716</idno>
<idno type="wicri:Area/PubMed/Corpus">000207</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000207</idno>
<idno type="wicri:Area/PubMed/Curation">000207</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000207</idno>
<idno type="wicri:Area/PubMed/Checkpoint">000207</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000207</idno>
<idno type="wicri:Area/Ncbi/Merge">001E09</idno>
<idno type="wicri:Area/Ncbi/Curation">001E09</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">001E09</idno>
<idno type="wicri:Area/Main/Merge">000431</idno>
<idno type="wicri:Area/Main/Curation">000430</idno>
<idno type="wicri:Area/Main/Exploration">000430</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">Bilateral deep brain stimulation of the fornix for Alzheimer's disease: surgical safety in the ADvance trial.</title>
<author><name sortKey="Ponce, Francisco A" sort="Ponce, Francisco A" uniqKey="Ponce F" first="Francisco A" last="Ponce">Francisco A. Ponce</name>
<affiliation><nlm:affiliation>Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona; </nlm:affiliation>
<wicri:noCountry code="subField">Arizona; </wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Asaad, Wael F" sort="Asaad, Wael F" uniqKey="Asaad W" first="Wael F" last="Asaad">Wael F. Asaad</name>
<affiliation><nlm:affiliation>Departments of 2 Neurosurgery and.</nlm:affiliation>
<wicri:noCountry code="no comma">Departments of 2 Neurosurgery and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Foote, Kelly D" sort="Foote, Kelly D" uniqKey="Foote K" first="Kelly D" last="Foote">Kelly D. Foote</name>
<affiliation><nlm:affiliation>Department of Neurosurgery, University of Florida, Gainesville, Florida; </nlm:affiliation>
<wicri:noCountry code="subField">Florida; </wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Anderson, William S" sort="Anderson, William S" uniqKey="Anderson W" first="William S" last="Anderson">William S. Anderson</name>
<affiliation><nlm:affiliation>Departments of 5 Neurological Surgery.</nlm:affiliation>
<wicri:noCountry code="no comma">Departments of 5 Neurological Surgery.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Rees Cosgrove, G" sort="Rees Cosgrove, G" uniqKey="Rees Cosgrove G" first="G" last="Rees Cosgrove">G. Rees Cosgrove</name>
<affiliation><nlm:affiliation>Departments of 2 Neurosurgery and.</nlm:affiliation>
<wicri:noCountry code="no comma">Departments of 2 Neurosurgery and.</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Baltuch, Gordon H" sort="Baltuch, Gordon H" uniqKey="Baltuch G" first="Gordon H" last="Baltuch">Gordon H. Baltuch</name>
<affiliation wicri:level="2"><nlm:affiliation>Department of Neurosurgery, University of Pennsylvania, Philadelphia, Pennsylvania;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Pennsylvanie</region>
</placeName>
<wicri:cityArea>Department of Neurosurgery, University of Pennsylvania, Philadelphia</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Beasley, Kara" sort="Beasley, Kara" uniqKey="Beasley K" first="Kara" last="Beasley">Kara Beasley</name>
<affiliation wicri:level="2"><nlm:affiliation>Boulder Neurosurgical & Spine Associates, Boulder, Colorado;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Colorado</region>
</placeName>
<wicri:cityArea>Boulder Neurosurgical & Spine Associates, Boulder</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Reymers, Donald E" sort="Reymers, Donald E" uniqKey="Reymers D" first="Donald E" last="Reymers">Donald E. Reymers</name>
<affiliation><nlm:affiliation>Functional Neuromodulation Ltd., Minneapolis, Minnesota; and.</nlm:affiliation>
<wicri:noCountry code="subField">Minnesota; and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Oh, Esther S" sort="Oh, Esther S" uniqKey="Oh E" first="Esther S" last="Oh">Esther S. Oh</name>
<affiliation><nlm:affiliation>Medicine, and.</nlm:affiliation>
<wicri:noCountry code="subField">and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Targum, Steven D" sort="Targum, Steven D" uniqKey="Targum S" first="Steven D" last="Targum">Steven D. Targum</name>
<affiliation><nlm:affiliation>Functional Neuromodulation Ltd., Minneapolis, Minnesota; and.</nlm:affiliation>
<wicri:noCountry code="subField">Minnesota; and</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Smith, Gwenn S" sort="Smith, Gwenn S" uniqKey="Smith G" first="Gwenn S" last="Smith">Gwenn S. Smith</name>
<affiliation wicri:level="2"><nlm:affiliation>Psychiatry, Johns Hopkins University, Baltimore, Maryland;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Psychiatry, Johns Hopkins University, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lyketsos, Constantine G" sort="Lyketsos, Constantine G" uniqKey="Lyketsos C" first="Constantine G" last="Lyketsos">Constantine G. Lyketsos</name>
<affiliation wicri:level="2"><nlm:affiliation>Psychiatry, Johns Hopkins University, Baltimore, Maryland;</nlm:affiliation>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Maryland</region>
</placeName>
<wicri:cityArea>Psychiatry, Johns Hopkins University, Baltimore</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name>
<affiliation wicri:level="4"><nlm:affiliation>Division of Neurosurgery, University of Toronto, Ontario, Canada.</nlm:affiliation>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Division of Neurosurgery, University of Toronto, Ontario</wicri:regionArea>
<orgName type="university">Université de Toronto</orgName>
<placeName><settlement type="city">Toronto</settlement>
<region type="state">Ontario</region>
</placeName>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of neurosurgery</title>
<idno type="eISSN">1933-0693</idno>
<imprint><date when="2016" type="published">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">OBJECT This report describes the stereotactic technique, hospitalization, and 90-day perioperative safety of bilateral deep brain stimulation (DBS) of the fornix in patients who underwent DBS for the treatment of mild, probable Alzheimer's disease (AD). METHODS The ADvance Trial is a multicenter, 12-month, double-blind, randomized, controlled feasibility study being conducted to evaluate the safety, efficacy, and tolerability of DBS of the fornix in patients with mild, probable AD. Intraoperative and perioperative data were collected prospectively. All patients underwent postoperative MRI. Stereotactic analyses were performed in a blinded fashion by a single surgeon. Adverse events (AEs) were reported to an independent clinical events committee and adjudicated to determine the relationship between the AE and the study procedure. RESULTS Between June 6, 2012, and April 28, 2014, a total of 42 patients with mild, probable AD were treated with bilateral fornix DBS (mean age 68.2 ± 7.8 years; range 48.0-79.7 years; 23 men and 19 women). The mean planned target coordinates were x = 5.2 ± 1.0 mm (range 3.0-7.9 mm), y = 9.6 ± 0.9 mm (range 8.0-11.6 mm), z = -7.5 ± 1.2 mm (range -5.4 to -10.0 mm), and the mean postoperative stereotactic radial error on MRI was 1.5 ± 1.0 mm (range 0.2-4.0 mm). The mean length of hospitalization was 1.4 ± 0.8 days. Twenty-six (61.9%) patients experienced 64 AEs related to the study procedure, of which 7 were serious AEs experienced by 5 patients (11.9%). Four (9.5%) patients required return to surgery: 2 patients for explantation due to infection, 1 patient for lead repositioning, and 1 patient for chronic subdural hematoma. No patients experienced neurological deficits as a result of the study, and no deaths were reported. CONCLUSIONS Accurate targeting of DBS to the fornix without direct injury to it is feasible across surgeons and treatment centers. At 90 days after surgery, bilateral fornix DBS was well tolerated by patients with mild, probable AD. Clinical trial registration no.: NCT01608061 ( clinicaltrials.gov ).</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
<li>États-Unis</li>
</country>
<region><li>Colorado</li>
<li>Maryland</li>
<li>Ontario</li>
<li>Pennsylvanie</li>
</region>
<settlement><li>Toronto</li>
</settlement>
<orgName><li>Université de Toronto</li>
</orgName>
</list>
<tree><noCountry><name sortKey="Anderson, William S" sort="Anderson, William S" uniqKey="Anderson W" first="William S" last="Anderson">William S. Anderson</name>
<name sortKey="Asaad, Wael F" sort="Asaad, Wael F" uniqKey="Asaad W" first="Wael F" last="Asaad">Wael F. Asaad</name>
<name sortKey="Foote, Kelly D" sort="Foote, Kelly D" uniqKey="Foote K" first="Kelly D" last="Foote">Kelly D. Foote</name>
<name sortKey="Oh, Esther S" sort="Oh, Esther S" uniqKey="Oh E" first="Esther S" last="Oh">Esther S. Oh</name>
<name sortKey="Ponce, Francisco A" sort="Ponce, Francisco A" uniqKey="Ponce F" first="Francisco A" last="Ponce">Francisco A. Ponce</name>
<name sortKey="Rees Cosgrove, G" sort="Rees Cosgrove, G" uniqKey="Rees Cosgrove G" first="G" last="Rees Cosgrove">G. Rees Cosgrove</name>
<name sortKey="Reymers, Donald E" sort="Reymers, Donald E" uniqKey="Reymers D" first="Donald E" last="Reymers">Donald E. Reymers</name>
<name sortKey="Targum, Steven D" sort="Targum, Steven D" uniqKey="Targum S" first="Steven D" last="Targum">Steven D. Targum</name>
</noCountry>
<country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Baltuch, Gordon H" sort="Baltuch, Gordon H" uniqKey="Baltuch G" first="Gordon H" last="Baltuch">Gordon H. Baltuch</name>
</region>
<name sortKey="Beasley, Kara" sort="Beasley, Kara" uniqKey="Beasley K" first="Kara" last="Beasley">Kara Beasley</name>
<name sortKey="Lyketsos, Constantine G" sort="Lyketsos, Constantine G" uniqKey="Lyketsos C" first="Constantine G" last="Lyketsos">Constantine G. Lyketsos</name>
<name sortKey="Smith, Gwenn S" sort="Smith, Gwenn S" uniqKey="Smith G" first="Gwenn S" last="Smith">Gwenn S. Smith</name>
</country>
<country name="Canada"><region name="Ontario"><name sortKey="Lozano, Andres M" sort="Lozano, Andres M" uniqKey="Lozano A" first="Andres M" last="Lozano">Andres M. Lozano</name>
</region>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000430 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000430 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Wicri/Canada
   |area=    ParkinsonCanadaV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     pubmed:26684775
   |texte=   Bilateral deep brain stimulation of the fornix for Alzheimer's disease: surgical safety in the ADvance trial.
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:26684775" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a ParkinsonCanadaV1

This area was generated with Dilib version V0.6.29.
Data generation: Thu May 4 22:20:19 2017. Site generation: Fri Dec 23 23:17:26 2022

La maladie de Parkinson au Canada (serveur d'exploration)

Bilateral deep brain stimulation of the fornix for Alzheimer's disease: surgical safety in the ADvance trial.

Bilateral deep brain stimulation of the fornix for Alzheimer's disease: surgical safety in the ADvance trial.

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	La maladie de Parkinson au Canada (serveur d'exploration)
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.